Perreando is the action of dancing perreo, the signature dance style of reggaeton music. This essential slang for any reggaeton fan comes from the Spanish word for dog, perro, referencing the dance's movements.
In the song's catchy chorus, Christina sings, "Que tú me tienes perreando" (You have me dancing perreo). She uses this word to describe how the person she's with makes her want to let loose and dance all night, perfectly capturing the fun, high-energy vibe of the song.
"Santo" brings Christina Aguilera and Puerto Rican star Ozuna straight onto a sweaty dance floor where neither of them wants to look at a clock. Christina starts off leaving past drama behind: "No pensaré en él, mucho menos en aquel" ("I won't think about him, much less that other guy"). Instead, she is fully locked into a mutual stare with someone new. The chorus turns mock-holy with "Santo, sálvame / Que tú me tienes perreando" ("Saint, save me / You've got me twerking"). She acts like she needs divine intervention to survive the intensity of the dancing, but she is clearly in control, adding "yo te digo hasta cuando" ("I'll tell you when to stop").
Ozuna jumps in with lines that escalate quickly, telling her to dance in high heels ("en tus tacos altos") and calling her "más peligrosa que el impacto de un rifle de asalto" ("more dangerous than the impact of an assault rifle"), which is absurd and dramatic in the best reggaeton way. He shouts out the Tejano legend Selena ("Me gusta reina como Selena" - "I like a queen like Selena") and borrows baseball slang with "robarte toda las bases" ("steal all your bases"). By the time they both vanish together into the dark ("Nos perdemos en la oscuridad"), the track has turned the club into an irresistible trance where the only rule is staying until someone finally cries mercy.