Desconfigura is a creative and modern verb you won't find in your textbook. It literally means "to deconfigure," like messing up the settings on a computer or phone.
In "LA FALDA," Myke Towers uses this tech term metaphorically. When he says, "Ella a mí me desconfigura", he means she completely messes with his head and throws him off balance, as if his brain has short-circuited just by seeing her. It’s a perfect example of modern slang mixing technology with attraction.
Puerto Rican rapper Myke Towers zeroes in on a girl who completely stops him in his tracks in "LA FALDA". The title literally means "The Skirt," and the entire track revolves around one tiny outfit: "Esa falda chiquitita, ay, qué bonita te queda" [That tiny skirt, oh, it looks so good on you]. He is obsessed with how she carries herself. She is working on her bachelor's degree ("ella está haciendo un bachillerato"), so he picks her up directly from university ("de la uni yo la saco") to drive her back to where she stays. Their hectic schedules mean they do not see each other every day anymore ("ahora es cuando se pueda" [now it's whenever we can]), which only makes their hookups more intense.
Myke keeps the details grounded, chaotic, and very real. She drinks, smokes, ignores haters who envy her, and unwinds in a foam-filled jacuzzi while blasting Mexican music star Peso Pluma ("Chingando escuchando a Peso Pluma" [Hooking up while listening to Peso Pluma]). He also drops shout-outs to his producers Yannc and Chalko while rolling up in a Ford Raptor truck. Slang flies everywhere here: he jokes that her attitude "me desconfigura" [messes with my settings / makes me lose control] and tells her to give other women room to shine because she commands the room without even trying. It is a loud, bold party track celebrating a driven student who knows exactly how good she looks.