Desespere comes from the reflexive verb desesperarse, which means to lose your patience or become desperate.
In this track, the singer calls out a manipulative ex by saying, "Yo sé que es lo que tú quieres, que yo me desespere" (I know what you want, for me to get desperate). It is a dramatic, emotionally charged word that perfectly captures the frustration of a complicated romance.
Colombian group Piso 21 and Manuel Turizo team up here to deliver the ultimate calm-before-the-rebound anthem. Instead of begging an ex to come back, the narrator leans back with supreme confidence. She walked away thinking he would fall apart, but he hits her with a blunt truth: Si fuiste tú quien se alejó, pero esta vez no me dolió, baby ("If you were the one who walked away, well this time it didn't hurt me, baby"). He even turns the tables on her ego, telling his friends not to chase after her with the hook Déjala que vuelva, ella conoce solita el camino conmigo ("Let her come back, she knows the way back to me all on her own").
That does not mean he forgot how much he likes her, though. He admits No hay nada más rico que probar tu boca ("There is nothing better than tasting your lips"), but he refuses to fold easily. He uses the playful Latin American term of endearment mamacita (literally "little mama," used casually like "babe" or "gorgeous") while setting firm boundaries: Pero esta vez, mamacita, no está fácil la cosa ("But this time, babe, things won't be so easy"). She wants him to panic and lose his head, but he knows she will be knocking on his door first.